Personalised Breast Cancer Prevention Plan

genetic testing

Take Control of Your Health with Personalised Prevention

Discover your unique genetic risk for breast cancer and receive tailored medical recommendations. Our personalised approach empowers you with effective strategies for prevention and early detection.

Why Choose Personalised Prevention?

Take the first step – order your personalised prevention plan today!

Understanding Breast Cancer SNP Testing

Unlocking Genetic Risk with Polygenic Risk Scores

Breast cancer SNP testing refers to analysing specific single nucleotide polymorphisms (SNPs)—which are variations at a single position in a DNA sequence—to assess genetic risk for developing breast cancer. SNPs (pronounced “snips”) are the most common type of genetic variation among people. Each SNP represents a difference in a single DNA building block (nucleotide)

Key points:

  • These SNPs often have small individual effects, but when combined, they can indicate a polygenic risk score.
  • This score helps stratify a person’s risk compared to the general population.

 

SNP testing for breast cancer is a personalised risk prediction tool, helpful for tailoring prevention and screening strategies. It’s part of the broader move toward precision medicine.

Testing a person SNP’s will provide a Polygenic Risk Score (PRS)

A Polygenic Risk Score (PRS) is a number that estimates a person’s genetic predisposition to a breast cancer, based on the presence of many small genetic variants (SNPs – single nucleotide polymorphisms). Unlike mutations in genes like BRCA1/2, which have large effects, PRS aggregates the tiny effects of many genes to assess risk.

Next-Generation Prevention

Tailored to Your Unique Genetic Profile

Personalised breast cancer prevention with genetic risk assessment provides early warnings, even in individuals with no family history of cancer. Our test guides you toward tailored screening and prevention strategies based on your unique risk level.

Comprehensive Insights Await You:

  • What is your genetic risk level for breast cancer?
  • When should you start breast cancer screening, and how often?
  • Are there additional measures you can take to lower your risk?
  • What steps can you take to reduce your likelihood of developing breast cancer?
  • What changes or symptoms should you monitor?
  • What should your doctor know?

Who Should Take This Test?

Simple Steps to Your Personalised Prevention Plan

Certified and Trusted Testing

Our tests are fully compliant with all regulatory bodies and government-approved:

  • CE-marked medical devices (in vitro diagnostics, IVD)
  • Registered in the UK MHRA Registry and EUDAMED database
  • Developed using anonymised data from the UK Biobank

STEP ONE

Order Your Test Kit

Delivered directly to your home.

STEP TWO

Provide a Sample

Use the simple saliva collection kit and return it using the prepaid envelope.

STEP THREE

Receive Your Personalised Report

Get your results online within six weeks, complete with clear guidance on your next steps.

PRS in Breast Cancer

  • Purpose: To estimate a woman’s lifetime risk of developing breast cancer.
  • How it’s calculated:
    • Based on genome-wide association studies (GWAS).
    • Involves analysing hundreds to thousands of SNPs.
    • Each SNP contributes a small risk factor.
  • Risk Stratification: Women are divided into risk categories (e.g., low, average, high) based on their PRS.

Clinical Applications

The Breast Awareness Clinic can offer;

  1. Screening recommendations: Women with high PRS might be advised to start mammograms earlier or more frequently.
  2. Risk prediction models: PRS can be added to models like BOADICEA, Tyrer-Cuzick (IBIS), or CanRisk, which also include lifestyle, family history, and other risk factors.
  3. Preventive strategies: Could influence decisions about lifestyle changes or prophylactic interventions in high-risk women.

The Reality of Breast Cancer

Breast cancer is the most common cancer in women, affecting 1 in 7 during their lifetime. 1 in 5 breast cancer cases affect women under 50, before routine screenings begin. Early detection can improve survival rates to over 99%.

We Can Change This – With Personalised Prevention!

Frequently Asked Questions

We hope this FAQ section answers your questions. However, if you have any additional inquiries or need further information, please don’t hesitate to get in touch.

How long is my saliva sample stable for during transit?

Saliva samples remain stable for up to 6 months under suitable conditions.

Once your sample is received at the laboratory, results are typically reported within 30 working days. If you haven’t received your results after this time, please contact us.

You can access your results online within 6 weeks. The notification about your results will be sent to the email address you provided. If needed, our medical team will contact you to arrange a convenient time to discuss your results.

No, the test evaluates your polygenic risk score but does not assess rare pathogenic mutations in genes such as BRCA1, BRCA2, and others that significantly increase cancer risk.

No, this test is designed to assess your genetic predisposition and provide personalised prevention strategies, not diagnose cancer.

No, an elevated risk does not guarantee you will develop breast cancer. Similarly, a moderate or lower risk does not mean your risk is zero.

No, the test evaluates your personal risk. Polygenic risk scores are not directly inherited in a way that can predict risks for relatives.

Your test results should be interpreted alongside other clinical data. Lifestyle, diet, and other health factors also play a role in breast cancer risk.